This came up on my newsfeed
https://www.abc.net.au/triplej/programs/hack/bodybuilding-supplement-norvaline-found-to-be-harmful/10800990
https://www.abc.net.au/triplej/programs/hack/bodybuilding-supplement-norvaline-found-to-be-harmful/10800990
Well, that thread explains some uses for it. It should increase pumps by inhibiting arginase (the enzyme that breaks down arginine). People take arginine, citrulline and agmatine because of Nitric Oxide. Arginase inhibition would allow those things to stay in the system for longer because the enzyme that breaks them down is imhibited.I don’t know why Norvaline still finds its way in supplements anyways.
https://anabolicminds.com/forum/supplements/235003-coops-corner-2-a.html
The overall conclusion, though, is that it’s relatively useless in healthy humans (as you alluded to). Really shouldn’t be included in future formulations IMOWell, that thread explains some uses for it. It should increase pumps by inhibiting arginase (the enzyme that breaks down arginine). People take arginine, citrulline and agmatine because of Nitric Oxide. Arginase inhibition would allow those things to stay in the system for longer because the enzyme that breaks them down is imhibited.
It may also have some use in things like Alzheimer's, infections and cardiovascular disease based on this inhibition.
But, it seems like its use may be more appropriate in a diseased state.
Isn’t that the same article/report that claimed some supplements had Snow Leopard in them lol? I’m highly skeptical of that one-off unsubstantiated report unless/until it is actually published as a case report.I also noticed
https://www.9news.com.au/2019/02/10/21/36/60-minutes-health-supplements-green-tea-could-cause-liver-failure
The video is interesting, apparently they found animal by-products in supplements. If you watch it, they also mention in the Chinese herbal products they found ephedrine, pharmaceuticals, steroids in 90%
This actually happened in my city/state. I know where that store is, definitely keen on some ephedrine
https://www.abc.net.au/news/2015-12-10/traditional-chinese-medicines-dangerous-chemical-contaminants/7015534Isn’t that the same article/report that claimed some supplements had Snow Leopard in them lol? I’m highly skeptical of that one-off unsubstantiated report unless/until it is actually published as a case report.
From the makers of Sex Panther, Odeon presents its foray into the realm of health supplements; SNOW LEOPARD. Illegal in nine counties, and made with bits of real snow leopard, so you know it’s good.
These were my thoughts as well. There seems to have been so many studies over the years showing benefits to Norvaline that it seems like if that study were legitimate that this type of information would have been seen a long time ago in other studies.I also saw the norvaline thing. It seems very interesting since cardiovascular health is important to having good mental health, and I thought norvaline was often prescribed for endothelial health. Haven't had time to look into it all...I may have had a misimderstanding.
Cooper did a great job of laying out some science on Norvaline. However, as you know, in today's world you can generally find studies to support or go against just about anything. I think the thing that's kept Norvaline around (in addition to the positive studies for cardiovascular benefits) is that it really does work great for many people.I don’t know why Norvaline still finds its way in supplements anyways.
https://anabolicminds.com/forum/supplements/235003-coops-corner-2-a.html
I'm legitimately curious on how the Norvaline discussion plays out and the validity/details of the study that got the debate started on it. Some of the wording I am seeing be quoted in articles related to this is very vague and the researchers have made statements or statements have been attributed to them that aren't just about norvaline but also about protein and other amino acids. There has been some research on the protective effects of Norvaline on certain aspects of brain health. It would be interesting to see if any of the places doing articles on this rather than just repeat each others articles would reach out to any of those researchers for comment.The overall conclusion, though, is that it’s relatively useless in healthy humans (as you alluded to). Really shouldn’t be included in future formulations IMO
I would say that the logic that cardiovascular patients may be more prone to the side effects is reasonable but may be incorrect.These were my thoughts as well. There seems to have been so many studies over the years showing benefits to Norvaline that it seems like if that study were legitimate that this type of information would have been seen a long time ago in other studies.
From what I've seen, many of the Norvaline studies for cardiovascular benefits were done in people with cardiovascular issues but logic would seem that that group would be even more at risk to potential side effects of use and if none were found in those groups, it makes me more skeptical.
Cooper did a great job of laying out some science on Norvaline. However, as you know, in today's world you can generally find studies to support or go against just about anything. I think the thing that's kept Norvaline around (in addition to the positive studies for cardiovascular benefits) is that it really does work great for many people.
I remember many years ago, I used something with Norvaline in it and was so surprised at how well it worked and wanted to see if it was actually the Norvaline so I bought Norvaline by NOW Foods to try it out and see. It worked really well for pumps (especially compared to other ingredients from the time period bc this was a long time ago) and also provided a noticeable effect in other areas.
I'm legitimately curious on how the Norvaline discussion plays out and the validity/details of the study that got the debate started on it. Some of the wording I am seeing be quoted in articles related to this is very vague and the researchers have made statements or statements have been attributed to them that aren't just about norvaline but also about protein and other amino acids. There has been some research on the protective effects of Norvaline on certain aspects of brain health. It would be interesting to see if any of the places doing articles on this rather than just repeat each others articles would reach out to any of those researchers for comment.
This puts companies in an interesting position because some of the best selling pre-workout and pump products on he market from major brands include Norvaline including Primeval Labs, Ghost, Controlled Labs, and more.
coops cornerI don’t know why Norvaline still finds its way in supplements anyways.
https://anabolicminds.com/forum/supplements/235003-coops-corner-2-a.html
Most of the studies that I've ever seen on Norvaline are for cardiovascular purposes or some for Alzheimer's and TBI patients. As with a lot of things, the crossover benefits can be inferred with certain things but not sure if its ever been studied specifically for pumps. I doubt that it has because its not a branded ingredient and generic ingredients rarely get studies done on them specifically for pumps because it isn't profitable in the sense of companies being able to buy it from any supplier versus needing to use a branded ingredient. I hope that makes sense.Are there even any positive studies for pumps/endurance/etc. in healthy subjects? I just don’t see the risk/reward balance being too good if there’s no actual studies showing it works in healthy humans, at least/especially if there are studies showing it doesn’t. If there are just no studies in healthy humans at all, then it’s a little more of a wild-card, but how many people swore CEE was the best thing since sliced bread at one point? Anecdotes often aren’t always very reliable.
I absolutely would not worry about Norvaline at all.Has there been any recent updates on norvaline's safety?
The latest research Ive found date from dec 2019 points out that it might be over exaggerated.
Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated
Recently, a study published in “Toxicology In Vitro” (Kate Samardzic and Kenneth J. Rodgers) was entitled: “Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline”. The title may be greatly ...www.ncbi.nlm.nih.gov
Any updates since? What would be a safe dosage?
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