Joint Support/Recovery Supplements that Don't Increase ACh or Inhibit AChE

[AndrewMcD]

Looking for some joint support and recovery ingredients that don't increase acetylcholine or inhibit acetylcholinesterase.

I'm highly susceptible to acetylcholine induced depression and anxiety.

I also have a gene polymorphism that doesn't help. Heterozygous for 'atypical' BuChE (rs1799807(A;G))

So many supplements, especially herbs are acetylcholinesterase inhibitors. It really sucks.

I'm feeling pretty beat up lately. Taking a de-load week. I kind of gave up on joint support and recovery compounds since most of the popular ones all seem to be. AchE inhibitors.

Turmeric:
In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer's disease.

https://pubmed.ncbi.nlm.nih.gov/28527659/

Ginger:

Our data also demonstrated that EtOAc fraction had the strongest antioxidant activity with IC50 was 8.89±1.37 µg/mL and AChE inhibitory activity with an IC50 value of 22.85±2.37 μg/mL in a dose-dependent manner, followed by BuOH fraction and the n-hexane fraction is the weakest.

https://pubmed.ncbi.nlm.nih.gov/29345437/

Boswellia

Bioassay-guided fractionation was carried out to isolate several boswellic acids, and their structures were determined spectroscopically. The boswellic acids showing the most inhibitory activity on acetylcholinesterase were 11α-hydroxy-β-boswellic acid (1) and 11-keto-β-boswellic acid.

Boswellic Acids with Acetylcholinesterase Inhibitory ...Sage Journalshttps://journals.sagepub.com › doi › pdf


Here’s a massive list published in the journal, Frontiers of Pharmacology, of natural AChE inhibitors and their relative strength. Berberine is one of the strongest.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201143/

Any recommendations would be very appreciated. As someone who really prefers natural remedies, I'm so limited because of how horrible high Achievers makes me feel./.

 

[Caliguns45]

Have you looked at cissus quadrangularis? I didn't see it on the list on pubmed. I searched to see if it was a acetylcholinesterase inhibitor but couldn't find anything.

 

[AndrewMcD]

Have you looked at cissus quadrangularis? I didn't see it on the list on pubmed. I searched to see if it was a acetylcholinesterase inhibitor but couldn't find anything.

All I could find was this very unhelpful old study: https://pubmed.ncbi.nlm.nih.gov/14112165/

 

[Caliguns45]

All I could find was this very unhelpful old study: https://pubmed.ncbi.nlm.nih.gov/14112165/

Maybe @sns8778 can chime in on this.

 

[sns8778]

Maybe @sns8778 can chime in on this.

Thanks. I’ll try to reply more to this on Monday. On weekends, if I check on here it’s usually from my phone and I don’t like to even try to do detailed posts from my phone.

I will say that I don’t think many of these ingredients are going to effect ach in a way that anyone is going to notice.

In todays world, it’s important to remember there are studies showing so many things, down to minute details that will never be noticed in real world applications and results.

 

[AndrewMcD]

Thanks. I’ll try to reply more to this on Monday. On weekends, if I check on here it’s usually from my phone and I don’t like to even try to do detailed posts from my phone.

I will say that I don’t think many of these ingredients are going to effect ach in a way that anyone is going to notice.

In todays world, it’s important to remember there are studies showing so many things, down to minute details that will never be noticed in real world applications and results.

I appreciate you Steve a ton! I cant tell you from personal experience these ingredients DO affect me in a very noticeable way. I've taken them in 100% isolation. And they bring me down to the point of feeling so depressed I can't even get out of bed.

Not saying this is everyone. Not at all. But there are definitely people sensitive to cholinergic.

 

[BCseacow83]

30g/day collagen

20-40mg/day UC-II

 

[sns8778]

I appreciate you Steve a ton! I cant tell you from personal experience these ingredients DO affect me in a very noticeable way. I've taken them in 100% isolation. And they bring me down to the point of feeling so depressed I can't even get out of bed.

Not saying this is everyone. Not at all. But there are definitely people sensitive to cholinergic.

I was talking about the subject in general. You’d already said you were hyper sensitive to things effecting your levels. I was saying that for 99.9% of people using them are never going to see a difference, good nor bad, in ach levels.

I can relate. I’m so sensitive to gluten, I could shake hands w you after you ate something with it in there and accidentally touch my mouth, eyes, or nose and it would bring on an autoimmune flareup. But even 99% of ppl with full blown Celiac aren’t as sensitive to trace amounts as I am.

 

[beholden]

Looking for some joint support and recovery ingredients that don't increase acetylcholine or inhibit acetylcholinesterase.

I'm highly susceptible to acetylcholine induced depression and anxiety.

I also have a gene polymorphism that doesn't help. Heterozygous for 'atypical' BuChE (rs1799807(A;G))

So many supplements, especially herbs are acetylcholinesterase inhibitors. It really sucks.

I'm feeling pretty beat up lately. Taking a de-load week. I kind of gave up on joint support and recovery compounds since most of the popular ones all seem to be. AchE inhibitors.

Turmeric:
In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer's disease.

https://pubmed.ncbi.nlm.nih.gov/28527659/

Ginger:

Our data also demonstrated that EtOAc fraction had the strongest antioxidant activity with IC50 was 8.89±1.37 µg/mL and AChE inhibitory activity with an IC50 value of 22.85±2.37 μg/mL in a dose-dependent manner, followed by BuOH fraction and the n-hexane fraction is the weakest.

https://pubmed.ncbi.nlm.nih.gov/29345437/

Boswellia

Bioassay-guided fractionation was carried out to isolate several boswellic acids, and their structures were determined spectroscopically. The boswellic acids showing the most inhibitory activity on acetylcholinesterase were 11α-hydroxy-β-boswellic acid (1) and 11-keto-β-boswellic acid.

Boswellic Acids with Acetylcholinesterase Inhibitory ...Sage Journalshttps://journals.sagepub.com › doi › pdf


Here’s a massive list published in the journal, Frontiers of Pharmacology, of natural AChE inhibitors and their relative strength. Berberine is one of the strongest.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201143/

Any recommendations would be very appreciated. As someone who really prefers natural remedies, I'm so limited because of how horrible high Achievers makes me feel./.

Have you looked into TB-500?